I don't believe so,
the email sender (the from address) does not exist in your system (either associated to a user or contact) and your configuration does not allow autoresponder processing from unknown sources - this is my email address, the system receives and send to this address without any other issues
the reference picked up in the email was not a valid reference (i.e it did not exist in the system) - the reference is valid, the same reference is used in the subject line and the rule triggers ok
the reference picked up in the email was a reference to a closed request and your configuration does not allow autoresponder processing on closed requests - nope the request was open