How do you run asset_rel_import.exe for weekly *updates* of relationship data

[SteveJM]

We have successfully created a set of relationships between our User Laptops and Desktop Applications (i.e. a One to Many relationship)

My question is, what is best practice for maintaining these relationships? Maybe with a weekly update run?
e.g. How do we cater for the following scenarios?
A user installs or uninstalls a new Desktop App.
A user upgrades Firefox from 127 to 128,
A laptop is lost, decommissioned or drops off AD

I see the removelinks section of the asset_rel_import.exe .JSON ...

Is it easier to remove ALL relationships between the 2 Asset Types and reload all again?
Or work out what the differences are and apply only those?
If we attempt to create a relationship that is already there will that cause an issue?
If we Decommission a Laptop (we have a Substate of decommissioned) will the links to Desktop Apps remain in situ?

What I am asking here is what is best practice for maintaining CMDB relationships?